منابع مشابه
Experimental autoimmune myasthenia gravis.
Injection of animals with purified acetylcholine receptor in complete Freund's adjuvant causes development of antibodies which crossreact with receptors in muscle. The crossreacting antibodies impair neuromuscular transmission. Animals with experimental autoimmune myasthenia gravis (EAMG) are excellent models for studying the complex mechanisms by which the autoimmune response to receptor in my...
متن کاملErythropoietin Ameliorates Experimental Autoimmune Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder characterized by weakness and fatigability of skeletal muscles. Erythropoietin (EPO) is a cytokine required to maintain erythroid cells. Recombinant human EPO (rHuEPO) was found to act also on immune cells. Beneficial effects of rHuEPO therapy have been demonstrated in several experimental autoimmune models. We have tested the effect of rHuEPO on...
متن کاملPathological Mechanisms in Experimental Autoimmune Myasthenia Gravis
Immunization of mammals with purified acetylcholine receptor protein (AChR) 1 results in an autoimmune response to skeletal muscle AChR which impairs neuromuscular transmission, causing experimental autoimmune myasthenia gravis (EAMG). In the introduction to the accompanying article (1) the striking similarities between EAMG and the human disease myasthenia gravis (MG) were reviewed. In that ar...
متن کاملO 29: Autoimmune Myasthenia Gravis Introduction, Immunopathogenesis and Classification
Autoimmune Myasthenia Gravis (MG) is a unique disease among all autoimmune disorders in two ways. First, there are a wide range of sub-specialties involved in the diagnosis and management of MG; secondly MG is an autoimmune disorder whose autoimmunity is well established. In this paper I will cover these topics: history and epidemiology of MG followed by a brief overview on physiology of neurom...
متن کاملExperimental autoimmune myasthenia gravis induction in B cell-deficient mice.
Experimental autoimmune myasthenia gravis (EAMG) is an animal model for human myasthenia gravis (MG). Autoantibody-induced functional loss of nicotinic acetylcholine receptor (AChR) at the postsynaptic membrane is an important pathogenic feature of both MG and EAMG. To evaluate the extent at which the humoral immune response against AChR operates in the pathogenesis of EAMG, we immunized B cell...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1980
ISSN: 0022-3050
DOI: 10.1136/jnnp.43.7.568